CYP4A11

Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016].
UniProt Summary: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). {ECO:0000269|PubMed:15611369, ECO:0000269|PubMed:1739747, ECO:0000269|PubMed:7679927}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

pressure natriuresis
leukotriene-B4 20-monooxygenase activity
leukotriene catabolic process
leukotriene B4 metabolic process
leukotriene B4 catabolic process
alkane 1-monooxygenase activity
icosanoid catabolic process
long-chain fatty acid catabolic process
omega-hydroxylase P450 pathway
fatty acid derivative catabolic process
renal system process involved in regulation of blood volume
arachidonic acid epoxygenase activity
positive regulation of icosanoid secretion
positive regulation of fatty acid transport
regulation of icosanoid secretion
epoxygenase P450 pathway
renal system process involved in regulation of systemic arterial blood pressure
regulation of fatty acid transport
leukotriene metabolic process
sodium ion homeostasis
positive regulation of organic acid transport
renal water homeostasis
positive regulation of anion transport
arachidonic acid metabolic process
regulation of organic acid transport
positive regulation of lipid transport
multicellular organismal water homeostasis
water homeostasis
organic hydroxy compound catabolic process
positive regulation of lipid localization
fatty acid catabolic process
regulation of systemic arterial blood pressure
regulation of anion transport
unsaturated fatty acid metabolic process
regulation of lipid transport
renal system process
icosanoid metabolic process
long-chain fatty acid metabolic process
monocarboxylic acid catabolic process
iron ion binding