CYP7A1 [The Human Chemical-Genetic Interaction Map Project]

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======= CYP7A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYP7A1
  * **<color #00a2e8>Official Name</color>**: cytochrome P450 family 7 subfamily A member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1581|1581]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22680|P22680]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYP7A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYP7A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118455|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis. {ECO:0000269|PubMed:19965590}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|p450|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cholesterol 7-alpha-monooxygenase activity|
|positive regulation of cholesterol biosynthetic process|
|positive regulation of sterol biosynthetic process|
|positive regulation of cholesterol metabolic process|
|regulation of bile acid biosynthetic process|
|regulation of bile acid metabolic process|
|cholesterol catabolic process|
|sterol catabolic process|
|negative regulation of fatty acid biosynthetic process|
|cellular response to cholesterol|
|positive regulation of steroid biosynthetic process|
|cellular response to sterol|
|positive regulation of alcohol biosynthetic process|
|negative regulation of fatty acid metabolic process|
|response to cholesterol|
|bile acid biosynthetic process|
|steroid catabolic process|
|positive regulation of steroid metabolic process|
|response to sterol|
|bile acid metabolic process|
|regulation of cholesterol biosynthetic process|
|regulation of sterol biosynthetic process|
|regulation of fatty acid biosynthetic process|
|negative regulation of lipid biosynthetic process|
|alcohol catabolic process|
|regulation of cholesterol metabolic process|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|regulation of alcohol biosynthetic process|
|organic hydroxy compound catabolic process|
|cholesterol homeostasis|
|positive regulation of lipid biosynthetic process|
|sterol homeostasis|
|cellular response to carbohydrate stimulus|
|negative regulation of lipid metabolic process|
|cellular response to alcohol|
|regulation of fatty acid metabolic process|
|cellular glucose homeostasis|
|regulation of steroid biosynthetic process|
|negative regulation of small molecule metabolic process|
|regulation of steroid metabolic process|
|cholesterol metabolic process|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|lipid homeostasis|
|iron ion binding|
|sterol metabolic process|
|response to glucose|
|positive regulation of small molecule metabolic process|
|heme binding|
|positive regulation of lipid metabolic process|
|response to hexose|
|response to monosaccharide|
|response to carbohydrate|
|regulation of cellular ketone metabolic process|
|glucose homeostasis|
|organic hydroxy compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|carbohydrate homeostasis|
|regulation of lipid biosynthetic process|
|response to alcohol|
|steroid metabolic process|
|lipid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|alcohol metabolic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|small molecule catabolic process|
|organic hydroxy compound metabolic process|
|organic cyclic compound catabolic process|
|cellular response to lipid|
|monocarboxylic acid metabolic process|
|cellular response to organic cyclic compound|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|intracellular membrane-bounded organelle|
|cellular chemical homeostasis|
|response to lipid|
|cellular homeostasis|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|chemical homeostasis|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|homeostatic process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5362
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYP7A1 Expression in NALM6 Cells: -2.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>