CYP7A1

Gene Information

Official Symbol: CYP7A1
Official Name: cytochrome P450 family 7 subfamily A member 1
Aliases and Previous Symbols: N/A
Entrez ID: 1581
UniProt: P22680
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010].
UniProt Summary: Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis. {ECO:0000269|PubMed:19965590}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5362
Expression level (log2 read counts): -2.84

Expression Distribution

cholesterol 7-alpha-monooxygenase activity
positive regulation of cholesterol biosynthetic process
positive regulation of sterol biosynthetic process
positive regulation of cholesterol metabolic process
regulation of bile acid biosynthetic process
regulation of bile acid metabolic process
cholesterol catabolic process
sterol catabolic process
negative regulation of fatty acid biosynthetic process
cellular response to cholesterol
positive regulation of steroid biosynthetic process
cellular response to sterol
positive regulation of alcohol biosynthetic process
negative regulation of fatty acid metabolic process
response to cholesterol
bile acid biosynthetic process
steroid catabolic process
positive regulation of steroid metabolic process
response to sterol
bile acid metabolic process
regulation of cholesterol biosynthetic process
regulation of sterol biosynthetic process
regulation of fatty acid biosynthetic process
negative regulation of lipid biosynthetic process
alcohol catabolic process
regulation of cholesterol metabolic process
cellular response to glucose stimulus
cellular response to hexose stimulus
cellular response to monosaccharide stimulus
regulation of alcohol biosynthetic process
organic hydroxy compound catabolic process
cholesterol homeostasis
positive regulation of lipid biosynthetic process
sterol homeostasis
cellular response to carbohydrate stimulus
negative regulation of lipid metabolic process
cellular response to alcohol
regulation of fatty acid metabolic process
cellular glucose homeostasis
regulation of steroid biosynthetic process