DAK [The Human Chemical-Genetic Interaction Map Project]

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======= DAK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TKFC
  * **<color #00a2e8>Official Name</color>**: triokinase and FMN cyclase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26007|26007]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q3LXA3|Q3LXA3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DAK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DAK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615844|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (PubMed:17600090). {ECO:0000250|UniProtKB:F1RKQ4, ECO:0000250|UniProtKB:Q4KLZ6, ECO:0000269|PubMed:16289032, ECO:0000269|PubMed:17600090, ECO:0000269|PubMed:4688871}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Dak1|
|Dak2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycerone kinase activity|
|triokinase activity|
|FAD-AMP lyase (cyclizing) activity|
|negative regulation of MDA-5 signaling pathway|
|fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate|
|fructose catabolic process|
|regulation of MDA-5 signaling pathway|
|glycerol catabolic process|
|glyceraldehyde-3-phosphate metabolic process|
|alditol catabolic process|
|negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|fructose metabolic process|
|regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|glycerol metabolic process|
|negative regulation of defense response to virus|
|carbohydrate phosphorylation|
|alditol metabolic process|
|polyol catabolic process|
|cellular carbohydrate catabolic process|
|hexose catabolic process|
|cellular aldehyde metabolic process|
|alcohol catabolic process|
|monosaccharide catabolic process|
|regulation of defense response to virus|
|organic hydroxy compound catabolic process|
|negative regulation of response to biotic stimulus|
|polyol metabolic process|
|carbohydrate catabolic process|
|negative regulation of immune effector process|
|hexose metabolic process|
|cellular carbohydrate metabolic process|
|monosaccharide metabolic process|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|alcohol metabolic process|
|negative regulation of response to external stimulus|
|small molecule catabolic process|
|negative regulation of immune system process|
|regulation of innate immune response|
|organic hydroxy compound metabolic process|
|regulation of immune effector process|
|carbohydrate metabolic process|
|negative regulation of intracellular signal transduction|
|regulation of response to biotic stimulus|
|regulation of cytokine production|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|organophosphate metabolic process|
|defense response to other organism|
|carbohydrate derivative metabolic process|
|regulation of response to external stimulus|
|regulation of immune response|
|negative regulation of signal transduction|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|ATP binding|
|negative regulation of response to stimulus|
|regulation of immune system process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14555
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DAK Expression in NALM6 Cells: 4.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>