DAK

Gene Information

Official Symbol: TKFC
Official Name: triokinase and FMN cyclase
Aliases and Previous Symbols: N/A
Entrez ID: 26007
UniProt: Q3LXA3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (PubMed:17600090). {ECO:0000250|UniProtKB:F1RKQ4, ECO:0000250|UniProtKB:Q4KLZ6, ECO:0000269|PubMed:16289032, ECO:0000269|PubMed:17600090, ECO:0000269|PubMed:4688871}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14555
Expression level (log2 read counts): 4.9

Expression Distribution

Dak1
Dak2

glycerone kinase activity
triokinase activity
FAD-AMP lyase (cyclizing) activity
negative regulation of MDA-5 signaling pathway
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
fructose catabolic process
regulation of MDA-5 signaling pathway
glycerol catabolic process
glyceraldehyde-3-phosphate metabolic process
alditol catabolic process
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
fructose metabolic process
regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
glycerol metabolic process
negative regulation of defense response to virus
carbohydrate phosphorylation
alditol metabolic process
polyol catabolic process
cellular carbohydrate catabolic process
hexose catabolic process
cellular aldehyde metabolic process
alcohol catabolic process
monosaccharide catabolic process
regulation of defense response to virus
organic hydroxy compound catabolic process
negative regulation of response to biotic stimulus
polyol metabolic process
carbohydrate catabolic process
negative regulation of immune effector process
hexose metabolic process
cellular carbohydrate metabolic process
monosaccharide metabolic process
negative regulation of defense response
negative regulation of multi-organism process
alcohol metabolic process
negative regulation of response to external stimulus
small molecule catabolic process
negative regulation of immune system process
regulation of innate immune response
organic hydroxy compound metabolic process