DAND5

Gene Information

Official Symbol: DAND5
Official Name: DAN domain BMP antagonist family member 5
Aliases and Previous Symbols: N/A
Entrez ID: 199699
UniProt: Q8N907
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2821
Expression level (log2 read counts): 1.97

Expression Distribution

Gene	Correlation
POLR2J3	0.512
TCEB3CL2	0.42
PSMB4	0.409
HIST2H3A	0.406
HIST2H3C	0.406
TCEB3C	0.405
RNF113A	0.403
TWISTNB	0.401

sequestering of nodal from receptor via nodal binding
negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
negative regulation of nodal signaling pathway involved in determination of left/right asymmetry
negative regulation of nodal signaling pathway
sequestering of BMP in extracellular matrix
regulation of nodal signaling pathway involved in determination of left/right asymmetry
regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
determination of left/right asymmetry in lateral mesoderm
morphogen activity
maintenance of protein location in extracellular region
regulation of nodal signaling pathway
negative regulation of mesoderm development
sequestering of extracellular ligand from receptor
negative regulation of activin receptor signaling pathway
extracellular negative regulation of signal transduction
extracellular regulation of signal transduction
lateral mesoderm development
regulation of mesoderm development
signal transduction involved in regulation of gene expression
atrial septum development
regulation of activin receptor signaling pathway
cardiac atrium development
negative regulation of BMP signaling pathway
determination of heart left/right asymmetry
ventricular septum development
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cellular response to transforming growth factor beta stimulus
regulation of BMP signaling pathway
maintenance of protein location
cardiac septum development
regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
determination of left/right symmetry
determination of bilateral symmetry
mesoderm development
specification of symmetry
cardiac ventricle development
negative regulation of cellular response to growth factor stimulus
maintenance of location