DBF4B

Gene Information

Official Symbol: DBF4B
Official Name: DBF4 zinc finger B
Aliases and Previous Symbols: N/A
Entrez ID: 80174
UniProt: Q8NFT6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:15668232, ECO:0000269|PubMed:17062569}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3641
Expression level (log2 read counts): 5.8

Expression Distribution

Screen	Score
Adefovir 20μM R07 exp332	1.86
UM131593 0.1μM R01 exp58	1.94
Golgicide-A 4μM R03 exp122	1.96

Dbf4-dependent protein kinase complex
positive regulation of nuclear cell cycle DNA replication
positive regulation of DNA-dependent DNA replication
regulation of nuclear cell cycle DNA replication
protein kinase activator activity
positive regulation of G2/M transition of mitotic cell cycle
protein serine/threonine kinase activator activity
positive regulation of cell cycle G2/M phase transition
positive regulation of DNA replication
aggresome
regulation of DNA-dependent DNA replication
positive regulation of mitotic cell cycle phase transition
positive regulation of cell cycle phase transition
regulation of DNA replication
positive regulation of mitotic cell cycle
nucleic acid binding
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
nuclear chromatin
positive regulation of cell cycle process
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
positive regulation of cell cycle
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
protein kinase binding
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of kinase activity
regulation of mitotic cell cycle
positive regulation of transferase activity
intracellular membrane-bounded organelle
regulation of cell cycle process
regulation of protein kinase activity
zinc ion binding
regulation of kinase activity
positive regulation of cell population proliferation
regulation of transferase activity
positive regulation of protein phosphorylation
positive regulation of phosphorylation