DCSTAMP

Gene Information

Official Symbol: DCSTAMP
Official Name: dendrocyte expressed seven transmembrane protein
Aliases and Previous Symbols: N/A
Entrez ID: 81501
UniProt: Q9H295
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7277
Expression level (log2 read counts): -6.02

Expression Distribution

Screen	Score
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.75
Dynasore 10μM R04 exp180	2.04
L-BMAA 500 to 750μM on day4 R04 exp185	3.01

positive regulation of macrophage fusion
regulation of macrophage fusion
osteoclast fusion
cellular response to macrophage colony-stimulating factor stimulus
response to macrophage colony-stimulating factor
multinuclear osteoclast differentiation
positive regulation of monocyte differentiation
positive regulation of bone resorption
positive regulation of bone remodeling
regulation of monocyte differentiation
myeloid dendritic cell differentiation
myeloid dendritic cell activation
positive regulation of syncytium formation by plasma membrane fusion
cellular response to interleukin-4
regulation of syncytium formation by plasma membrane fusion
response to interleukin-4
positive regulation of tissue remodeling
dendritic cell differentiation
cell-cell fusion
syncytium formation by plasma membrane fusion
syncytium formation
regulation of bone resorption
osteoclast differentiation
regulation of bone remodeling
positive regulation of myeloid leukocyte differentiation
endoplasmic reticulum-Golgi intermediate compartment membrane
regulation of tissue remodeling
positive regulation of myeloid cell differentiation
integral component of endoplasmic reticulum membrane
myeloid leukocyte differentiation
regulation of myeloid leukocyte differentiation
membrane fusion
positive regulation of leukocyte differentiation
negative regulation of cell growth
positive regulation of hemopoiesis
endosome membrane
myeloid cell differentiation
regulation of myeloid cell differentiation
cellular response to tumor necrosis factor
negative regulation of growth