DDC

Entrez Summary: The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011].
UniProt Summary: Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
MS023 7μM R03 exp135	-1.72
SB743921 0.001μM R05 exp244	1.96

Pyridoxal deC
Beta elim lyase

L-dopa decarboxylase activity
aromatic-L-amino-acid decarboxylase activity
phytoalexin metabolic process
isoquinoline alkaloid metabolic process
serotonin biosynthetic process
aminergic neurotransmitter loading into synaptic vesicle
response to pyrethroid
indolalkylamine biosynthetic process
primary amino compound biosynthetic process
indole-containing compound biosynthetic process
amine transport
alkaloid metabolic process
neurotransmitter loading into synaptic vesicle
serotonin metabolic process
dopamine biosynthetic process
primary amino compound metabolic process
response to insecticide
indolalkylamine metabolic process
amino acid binding
catecholamine biosynthetic process
catechol-containing compound biosynthetic process
cellular biogenic amine biosynthetic process
toxin metabolic process
indole-containing compound metabolic process
amine biosynthetic process
dopamine metabolic process
phenol-containing compound biosynthetic process
cellular response to alkaloid
multicellular organism aging
neurotransmitter biosynthetic process
catecholamine metabolic process
catechol-containing compound metabolic process
pyridoxal phosphate binding
secondary metabolic process
cellular biogenic amine metabolic process
cellular amine metabolic process
amine metabolic process
phenol-containing compound metabolic process
neurotransmitter metabolic process
response to alkaloid