DDX3Y
Gene Information
- Official Symbol: DDX3Y
- Official Name: DEAD-box helicase 3 Y-linked
- Aliases and Previous Symbols: N/A
- Entrez ID: 8653
- UniProt: O15523
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the DEAD-box RNA helicase family, characterized by nine conserved motifs, included the conserved Asp-Glu-Ala-Asp (DEAD) motif. These motifs are thought to be involved in ATP binding, hydrolysis, RNA binding, and in the formation of intramolecular interactions. This protein shares high similarity to DDX3X, on the X chromosome, but a deletion of this gene is not complemented by DDX3X. Mutations in this gene result in male infertility, a reduction in germ cell numbers, and can result in Sertoli-cell only sydrome. Pseudogenes sharing similarity to both this gene and the DDX3X paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014].
- UniProt Summary: Probable ATP-dependent RNA helicase. May play a role in spermatogenesis.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 14859
- Expression level (log2 read counts): 7.9
DDX3Y Expression in NALM6 Cells: 7.9
