DEGS1 [The Human Chemical-Genetic Interaction Map Project]

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======= DEGS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DEGS1
  * **<color #00a2e8>Official Name</color>**: delta 4-desaturase, sphingolipid 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8560|8560]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15121|O15121]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DEGS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DEGS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615843|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). {ECO:0000269|PubMed:11937514}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FA desaturase|
|Lipid DES|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sphingolipid delta-4 desaturase activity|
|unsaturated fatty acid biosynthetic process|
|ceramide biosynthetic process|
|electron transfer activity|
|ceramide metabolic process|
|sphingolipid biosynthetic process|
|specific granule membrane|
|unsaturated fatty acid metabolic process|
|fatty acid biosynthetic process|
|membrane lipid biosynthetic process|
|sphingolipid metabolic process|
|electron transport chain|
|monocarboxylic acid biosynthetic process|
|membrane lipid metabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|fatty acid metabolic process|
|generation of precursor metabolites and energy|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|amide biosynthetic process|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|myeloid leukocyte activation|
|small molecule biosynthetic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|cellular amide metabolic process|
|exocytosis|
|carboxylic acid metabolic process|
|leukocyte activation|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|secretion by cell|
|endoplasmic reticulum|
|organic acid metabolic process|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|lipid metabolic process|
|mitochondrion|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.72|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.77|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.77|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.8|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.87|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.88|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.88|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.96|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.97|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|2.01|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.06|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.24|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.48|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.52|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.7|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.71|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|3.14|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.442|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13382
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DEGS1 Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>