DEGS1

Entrez Summary: N/A
UniProt Summary: Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). {ECO:0000269|PubMed:11937514}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pimelic-diphenylamide-106 5μM R00 exp28	1.72
Clomiphene 4.4μM R02 exp68	1.77
Staurosporine 0.02μM R08 exp524	1.77
MLN-4924 0.2μM R00 exp21	1.8
Nocodazole 0.02μM R00 exp23	1.87
Azithromycin 100μM R08 exp452	1.88
Momordin-Ic 10μM R08 exp506	1.88
Vemurafenib 6.6μM R02 exp89	1.96
5-Fluorouracil 20μM R00 exp2	1.97
THZ531 0.11μM R07 exp409	2.01
MLN-4924 2μM R00 exp22	2.06
Colchicine 0.009μM R05 exp215	2.24
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.48
Pyridostatin 4μM R05 exp240	2.52
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.7
Vincristine 0.0005μM R04 exp190	2.71
THZ531 0.225μM R08 exp444	3.14
Tubacin 1.6μM R07 exp416	4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

FA desaturase
Lipid DES

sphingolipid delta-4 desaturase activity
unsaturated fatty acid biosynthetic process
ceramide biosynthetic process
electron transfer activity
ceramide metabolic process
sphingolipid biosynthetic process
specific granule membrane
unsaturated fatty acid metabolic process
fatty acid biosynthetic process
membrane lipid biosynthetic process
sphingolipid metabolic process
electron transport chain
monocarboxylic acid biosynthetic process
membrane lipid metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
generation of precursor metabolites and energy
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
amide biosynthetic process
monocarboxylic acid metabolic process
lipid biosynthetic process
myeloid leukocyte activation
small molecule biosynthetic process
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
leukocyte mediated immunity
cellular amide metabolic process
exocytosis
carboxylic acid metabolic process
leukocyte activation
endoplasmic reticulum membrane