DGCR2
Gene Information
- Official Symbol: DGCR2
- Official Name: DiGeorge syndrome critical region gene 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 9993
- UniProt: P98153
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
- UniProt Summary: Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4580
- Expression level (log2 read counts): 6.79
DGCR2 Expression in NALM6 Cells: 6.79
