DGCR8

Entrez Summary: This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

microprocessor complex
ribonuclease III activity
primary miRNA binding
primary miRNA processing
miRNA metabolic process
production of miRNAs involved in gene silencing by miRNA
dsRNA processing
production of small RNA involved in gene silencing by RNA
gene silencing by miRNA
posttranscriptional gene silencing by RNA
posttranscriptional gene silencing
double-stranded RNA binding
RNA phosphodiester bond hydrolysis, endonucleolytic
gene silencing by RNA
heme binding
gene silencing
RNA phosphodiester bond hydrolysis
regulation of gene expression, epigenetic
nucleic acid phosphodiester bond hydrolysis
ncRNA processing
ncRNA metabolic process
posttranscriptional regulation of gene expression
nucleolus
RNA processing
protein homodimerization activity
identical protein binding
RNA metabolic process
negative regulation of gene expression
gene expression