DGKE [The Human Chemical-Genetic Interaction Map Project]

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======= DGKE =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DGKE
  * **<color #00a2e8>Official Name</color>**: diacylglycerol kinase epsilon
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8526|8526]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52429|P52429]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DGKE&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DGKE|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601440|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DAGK cat|
|C1 1|
|DAGK acc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|diacylglycerol kinase activity|
|NAD+ kinase activity|
|diacylglycerol metabolic process|
|protein kinase C-activating G protein-coupled receptor signaling pathway|
|lipid phosphorylation|
|kinase activity|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|platelet activation|
|lipid modification|
|phospholipid biosynthetic process|
|blood coagulation|
|coagulation|
|hemostasis|
|glutamatergic synapse|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|wound healing|
|regulation of body fluid levels|
|organophosphate biosynthetic process|
|response to wounding|
|lipid biosynthetic process|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|cell activation|
|lipid metabolic process|
|phosphorylation|
|G protein-coupled receptor signaling pathway|
|ATP binding|
|intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.89|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2870
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DGKE Expression in NALM6 Cells: 6.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>