DGKE

Entrez Summary: Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. [provided by RefSeq, Jul 2008].
UniProt Summary: Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
DABN 20μM R00 exp17	-1.89
proTAME 5μM R04 exp187	1.83

diacylglycerol kinase activity
NAD+ kinase activity
diacylglycerol metabolic process
protein kinase C-activating G protein-coupled receptor signaling pathway
lipid phosphorylation
kinase activity
acylglycerol metabolic process
neutral lipid metabolic process
platelet activation
lipid modification
phospholipid biosynthetic process
blood coagulation
coagulation
hemostasis
glutamatergic synapse
phospholipid metabolic process
glycerolipid metabolic process
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
wound healing
regulation of body fluid levels
organophosphate biosynthetic process
response to wounding
lipid biosynthetic process
organophosphate metabolic process
cellular lipid metabolic process
cell activation
lipid metabolic process
phosphorylation
G protein-coupled receptor signaling pathway
ATP binding
intracellular signal transduction
membrane