DHFRL1

Entrez Summary: N/A
UniProt Summary: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR. {ECO:0000269|PubMed:21876184, ECO:0000269|PubMed:21876188}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

deoxyribonucleoside biosynthetic process
dihydrofolate reductase activity
pyrimidine deoxyribonucleoside biosynthetic process
thymidine biosynthetic process
dihydrofolate metabolic process
pyrimidine deoxyribonucleoside metabolic process
thymidine metabolic process
tetrahydrofolate biosynthetic process
deoxyribonucleoside metabolic process
folic acid-containing compound biosynthetic process
pteridine-containing compound biosynthetic process
pyrimidine nucleoside biosynthetic process
tetrahydrofolate metabolic process
folic acid metabolic process
one-carbon metabolic process
folic acid-containing compound metabolic process
pteridine-containing compound metabolic process
NADP binding
pyrimidine nucleoside metabolic process
nucleoside biosynthetic process
glycosyl compound biosynthetic process
cellular modified amino acid biosynthetic process
pyrimidine-containing compound biosynthetic process
water-soluble vitamin metabolic process
dicarboxylic acid metabolic process
nucleobase-containing small molecule biosynthetic process
pyrimidine-containing compound metabolic process
nucleoside metabolic process
vitamin metabolic process
glycosyl compound metabolic process
coenzyme biosynthetic process
mRNA binding
cellular modified amino acid metabolic process
cofactor biosynthetic process
coenzyme metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
mitochondrial matrix
mitochondrial inner membrane
cofactor metabolic process