DHX58

Gene Information

Official Symbol: DHX58
Official Name: DExH-box helicase 58
Aliases and Previous Symbols: N/A
Entrez ID: 79132
UniProt: Q96C10
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate. {ECO:0000269|PubMed:16116171, ECO:0000269|PubMed:17020950, ECO:0000269|PubMed:17190814, ECO:0000269|PubMed:18411269, ECO:0000269|PubMed:19208642, ECO:0000269|PubMed:19211564, ECO:0000269|PubMed:19278996, ECO:0000269|PubMed:19380577, ECO:0000269|PubMed:21187438, ECO:0000269|PubMed:21525357}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6853
Expression level (log2 read counts): 3.03

Expression Distribution

RIG-I C-RD
Helicase C
ResIII
DEAD

positive regulation of MDA-5 signaling pathway
negative regulation of MDA-5 signaling pathway
regulation of MDA-5 signaling pathway
negative regulation of RIG-I signaling pathway
positive regulation of RIG-I signaling pathway
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
regulation of RIG-I signaling pathway
regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
negative regulation of defense response to virus
negative regulation of type I interferon production
single-stranded RNA binding
negative regulation of innate immune response
RNA helicase activity
double-stranded RNA binding
regulation of defense response to virus
positive regulation of type I interferon production
negative regulation of response to biotic stimulus
negative regulation of immune effector process
regulation of type I interferon production
negative regulation of immune response
defense response to virus
negative regulation of defense response
negative regulation of multi-organism process
positive regulation of immune effector process
negative regulation of cytokine production
response to virus
positive regulation of innate immune response
positive regulation of response to biotic stimulus
negative regulation of response to external stimulus
negative regulation of immune system process
positive regulation of cytokine production
regulation of innate immune response
regulation of immune effector process
positive regulation of defense response
negative regulation of intracellular signal transduction
positive regulation of multi-organism process
regulation of response to biotic stimulus
positive regulation of response to external stimulus
response to bacterium
regulation of cytokine production