DIO3 [The Human Chemical-Genetic Interaction Map Project]

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======= DIO3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DIO3
  * **<color #00a2e8>Official Name</color>**: iodothyronine deiodinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1735|1735]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55073|P55073]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DIO3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DIO3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601038|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. {ECO:0000269|PubMed:7593630}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|T4 deiodinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|thyroid hormone catabolic process|
|retinal cone cell apoptotic process|
|regulation of eye photoreceptor cell development|
|negative regulation of eye photoreceptor cell development|
|retinal cell apoptotic process|
|thyroxine 5-deiodinase activity|
|negative regulation of photoreceptor cell differentiation|
|regulation of photoreceptor cell differentiation|
|retinal cone cell differentiation|
|retinal cone cell development|
|thyroid hormone generation|
|phenol-containing compound catabolic process|
|hormone catabolic process|
|thyroid hormone metabolic process|
|camera-type eye photoreceptor cell differentiation|
|cellular modified amino acid catabolic process|
|positive regulation of multicellular organism growth|
|eye photoreceptor cell development|
|negative regulation of animal organ morphogenesis|
|neuron apoptotic process|
|eye photoreceptor cell differentiation|
|photoreceptor cell development|
|retina morphogenesis in camera-type eye|
|neuron death|
|neural retina development|
|photoreceptor cell differentiation|
|hormone biosynthetic process|
|regulation of multicellular organism growth|
|organic hydroxy compound catabolic process|
|phenol-containing compound metabolic process|
|camera-type eye morphogenesis|
|retina development in camera-type eye|
|eye morphogenesis|
|positive regulation of developmental growth|
|cellular modified amino acid metabolic process|
|hormone metabolic process|
|endosome membrane|
|negative regulation of neuron differentiation|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|positive regulation of growth|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|camera-type eye development|
|regulation of developmental growth|
|negative regulation of cell development|
|eye development|
|visual system development|
|sensory system development|
|aromatic compound catabolic process|
|organic hydroxy compound metabolic process|
|organic cyclic compound catabolic process|
|regulation of hormone levels|
|sensory organ development|
|regulation of neuron differentiation|
|regulation of growth|
|negative regulation of cell differentiation|
|neuron development|
|regulation of neurogenesis|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|oxidation-reduction process|
|neuron differentiation|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|cell death|
|negative regulation of multicellular organismal process|
|positive regulation of developmental process|
|generation of neurons|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11901
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DIO3 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>