DIO3

Entrez Summary: N/A
UniProt Summary: Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. {ECO:0000269|PubMed:7593630}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

thyroid hormone catabolic process
retinal cone cell apoptotic process
regulation of eye photoreceptor cell development
negative regulation of eye photoreceptor cell development
retinal cell apoptotic process
thyroxine 5-deiodinase activity
negative regulation of photoreceptor cell differentiation
regulation of photoreceptor cell differentiation
retinal cone cell differentiation
retinal cone cell development
thyroid hormone generation
phenol-containing compound catabolic process
hormone catabolic process
thyroid hormone metabolic process
camera-type eye photoreceptor cell differentiation
cellular modified amino acid catabolic process
positive regulation of multicellular organism growth
eye photoreceptor cell development
negative regulation of animal organ morphogenesis
neuron apoptotic process
eye photoreceptor cell differentiation
photoreceptor cell development
retina morphogenesis in camera-type eye
neuron death
neural retina development
photoreceptor cell differentiation
hormone biosynthetic process
regulation of multicellular organism growth
organic hydroxy compound catabolic process
phenol-containing compound metabolic process
camera-type eye morphogenesis
retina development in camera-type eye
eye morphogenesis
positive regulation of developmental growth
cellular modified amino acid metabolic process
hormone metabolic process
endosome membrane
negative regulation of neuron differentiation
sensory organ morphogenesis
regulation of animal organ morphogenesis