DIXDC1 [The Human Chemical-Genetic Interaction Map Project]

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======= DIXDC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DIXDC1
  * **<color #00a2e8>Official Name</color>**: DIX domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=85458|85458]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q155Q3|Q155Q3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DIXDC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DIXDC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610493|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|forebrain ventricular zone progenitor cell division|
|gamma-tubulin binding|
|cell proliferation in forebrain|
|cerebral cortex radially oriented cell migration|
|cerebral cortex cell migration|
|telencephalon cell migration|
|forebrain cell migration|
|neural precursor cell proliferation|
|canonical Wnt signaling pathway|
|cerebral cortex development|
|pallium development|
|positive regulation of Wnt signaling pathway|
|regulation of microtubule cytoskeleton organization|
|regulation of microtubule-based process|
|negative regulation of neuron differentiation|
|protein domain specific binding|
|telencephalon development|
|actin binding|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|negative regulation of cell development|
|regulation of actin cytoskeleton organization|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|cytoskeleton|
|forebrain development|
|regulation of actin filament-based process|
|focal adhesion|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|cell division|
|regulation of cytoskeleton organization|
|cell population proliferation|
|regulation of neuron differentiation|
|negative regulation of cell differentiation|
|brain development|
|head development|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cell migration|
|central nervous system development|
|localization of cell|
|cell motility|
|cell-cell signaling|
|negative regulation of multicellular organismal process|
|regulation of organelle organization|
|locomotion|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|positive regulation of signal transduction|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.81|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18274
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DIXDC1 Expression in NALM6 Cells: 3.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>