DIXDC1

Entrez Summary: The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.81
Dexamethasone 0.006μM R07 exp351	1.84

forebrain ventricular zone progenitor cell division
gamma-tubulin binding
cell proliferation in forebrain
cerebral cortex radially oriented cell migration
cerebral cortex cell migration
telencephalon cell migration
forebrain cell migration
neural precursor cell proliferation
canonical Wnt signaling pathway
cerebral cortex development
pallium development
positive regulation of Wnt signaling pathway
regulation of microtubule cytoskeleton organization
regulation of microtubule-based process
negative regulation of neuron differentiation
protein domain specific binding
telencephalon development
actin binding
negative regulation of neurogenesis
negative regulation of nervous system development
negative regulation of cell development
regulation of actin cytoskeleton organization
Wnt signaling pathway
cell-cell signaling by wnt
regulation of Wnt signaling pathway
cytoskeleton
forebrain development
regulation of actin filament-based process
focal adhesion
cell surface receptor signaling pathway involved in cell-cell signaling
cell division
regulation of cytoskeleton organization
cell population proliferation
regulation of neuron differentiation
negative regulation of cell differentiation
brain development
head development
regulation of neurogenesis
regulation of nervous system development
regulation of cell development