DKKL1 [The Human Chemical-Genetic Interaction Map Project]

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======= DKKL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DKKL1
  * **<color #00a2e8>Official Name</color>**: dickkopf like acrosomal protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27120|27120]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UK85|Q9UK85]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DKKL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DKKL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605418|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility. {ECO:0000250|UniProtKB:Q9QZL9}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of testosterone biosynthetic process|
|regulation of testosterone biosynthetic process|
|penetration of zona pellucida|
|negative regulation of hormone biosynthetic process|
|negative regulation of hormone metabolic process|
|co-receptor binding|
|regulation of ketone biosynthetic process|
|negative regulation of steroid biosynthetic process|
|negative regulation of steroid metabolic process|
|regulation of hormone biosynthetic process|
|receptor antagonist activity|
|regulation of hormone metabolic process|
|negative regulation of lipid biosynthetic process|
|negative regulation of signaling receptor activity|
|positive regulation of fat cell differentiation|
|negative regulation of lipid metabolic process|
|acrosomal vesicle|
|regulation of steroid biosynthetic process|
|negative regulation of small molecule metabolic process|
|regulation of steroid metabolic process|
|regulation of fat cell differentiation|
|single fertilization|
|fertilization|
|regulation of cellular ketone metabolic process|
|regulation of signaling receptor activity|
|negative regulation of canonical Wnt signaling pathway|
|regulation of lipid biosynthetic process|
|negative regulation of Wnt signaling pathway|
|multi-multicellular organism process|
|regulation of canonical Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|regulation of hormone levels|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|positive regulation of cell differentiation|
|multi-organism reproductive process|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|extracellular space|
|negative regulation of response to stimulus|
|regulation of cell death|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.79|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10708
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DKKL1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>