DKKL1

Gene Information

Official Symbol: DKKL1
Official Name: dickkopf like acrosomal protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 27120
UniProt: Q9UK85
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility. {ECO:0000250|UniProtKB:Q9QZL9}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10708
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
Dimethyloxaloylglycine 100μM R05 exp229	-1.79
Bafilomycin-A1 0.009μM R08 exp454	1.94

negative regulation of testosterone biosynthetic process
regulation of testosterone biosynthetic process
penetration of zona pellucida
negative regulation of hormone biosynthetic process
negative regulation of hormone metabolic process
co-receptor binding
regulation of ketone biosynthetic process
negative regulation of steroid biosynthetic process
negative regulation of steroid metabolic process
regulation of hormone biosynthetic process
receptor antagonist activity
regulation of hormone metabolic process
negative regulation of lipid biosynthetic process
negative regulation of signaling receptor activity
positive regulation of fat cell differentiation
negative regulation of lipid metabolic process
acrosomal vesicle
regulation of steroid biosynthetic process
negative regulation of small molecule metabolic process
regulation of steroid metabolic process
regulation of fat cell differentiation
single fertilization
fertilization
regulation of cellular ketone metabolic process
regulation of signaling receptor activity
negative regulation of canonical Wnt signaling pathway
regulation of lipid biosynthetic process
negative regulation of Wnt signaling pathway
multi-multicellular organism process
regulation of canonical Wnt signaling pathway
regulation of Wnt signaling pathway
regulation of lipid metabolic process
regulation of small molecule metabolic process
regulation of hormone levels
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction