DNAJB6 [The Human Chemical-Genetic Interaction Map Project]

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======= DNAJB6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAJB6
  * **<color #00a2e8>Official Name</color>**: DnaJ heat shock protein family (Hsp40) member B6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10049|10049]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75190|O75190]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAJB6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAJB6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611332|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DnaJ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|syncytiotrophoblast cell differentiation involved in labyrinthine layer development|
|chorion development|
|chorio-allantoic fusion|
|extraembryonic membrane development|
|negative regulation of inclusion body assembly|
|regulation of inclusion body assembly|
|labyrinthine layer morphogenesis|
|intermediate filament organization|
|ATPase activator activity|
|embryonic placenta morphogenesis|
|cell differentiation involved in embryonic placenta development|
|labyrinthine layer development|
|intermediate filament cytoskeleton organization|
|intermediate filament-based process|
|positive regulation of ATPase activity|
|heat shock protein binding|
|regulation of cellular response to heat|
|regulation of ATPase activity|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|embryonic placenta development|
|negative regulation of cysteine-type endopeptidase activity|
|chaperone binding|
|Z disc|
|unfolded protein binding|
|placenta development|
|protein localization to nucleus|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|protein folding|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|extracellular matrix organization|
|negative regulation of proteolysis|
|in utero embryonic development|
|extracellular structure organization|
|regulation of endopeptidase activity|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|supramolecular fiber organization|
|actin cytoskeleton organization|
|cell-cell adhesion|
|embryonic morphogenesis|
|actin filament-based process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of proteolysis|
|protein localization to organelle|
|regulation of cellular response to stress|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|cell adhesion|
|biological adhesion|
|regulation of cellular component biogenesis|
|embryo development|
|negative regulation of cell death|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of hydrolase activity|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of molecular function|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tkt|TKT]]|0.446|
|[[:human genes:c:c14orf80|C14orf80]]|0.44|
|[[:human genes:r:rpe|RPE]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3299
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAJB6 Expression in NALM6 Cells: 6.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>