DNAJB6

Entrez Summary: This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 7/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	1/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

syncytiotrophoblast cell differentiation involved in labyrinthine layer development
chorion development
chorio-allantoic fusion
extraembryonic membrane development
negative regulation of inclusion body assembly
regulation of inclusion body assembly
labyrinthine layer morphogenesis
intermediate filament organization
ATPase activator activity
embryonic placenta morphogenesis
cell differentiation involved in embryonic placenta development
labyrinthine layer development
intermediate filament cytoskeleton organization
intermediate filament-based process
positive regulation of ATPase activity
heat shock protein binding
regulation of cellular response to heat
regulation of ATPase activity
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
embryonic placenta development
negative regulation of cysteine-type endopeptidase activity
chaperone binding
Z disc
unfolded protein binding
placenta development
protein localization to nucleus
regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein folding
regulation of cysteine-type endopeptidase activity
negative regulation of endopeptidase activity
negative regulation of peptidase activity
extracellular matrix organization
negative regulation of proteolysis
in utero embryonic development
extracellular structure organization
regulation of endopeptidase activity
reproductive structure development
reproductive system development
embryonic organ development
regulation of peptidase activity