DNAJB9 [The Human Chemical-Genetic Interaction Map Project]

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======= DNAJB9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAJB9
  * **<color #00a2e8>Official Name</color>**: DnaJ heat shock protein family (Hsp40) member B9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4189|4189]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBS3|Q9UBS3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAJB9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAJB9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602634|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity). {ECO:0000250|UniProtKB:G3H0N9, ECO:0000250|UniProtKB:Q9QYI6, ECO:0000269|PubMed:18400946}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DnaJ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of IRE1-mediated unfolded protein response|
|negative regulation of endoplasmic reticulum unfolded protein response|
|regulation of IRE1-mediated unfolded protein response|
|regulation of endoplasmic reticulum unfolded protein response|
|misfolded protein binding|
|Hsp70 protein binding|
|negative regulation of response to endoplasmic reticulum stress|
|IRE1-mediated unfolded protein response|
|ubiquitin-dependent ERAD pathway|
|regulation of response to endoplasmic reticulum stress|
|ERAD pathway|
|chaperone binding|
|endoplasmic reticulum unfolded protein response|
|B cell differentiation|
|cellular response to unfolded protein|
|cellular response to topologically incorrect protein|
|B cell activation|
|immunoglobulin production|
|response to unfolded protein|
|production of molecular mediator of immune response|
|response to topologically incorrect protein|
|lymphocyte differentiation|
|response to endoplasmic reticulum stress|
|endoplasmic reticulum lumen|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|leukocyte differentiation|
|proteasomal protein catabolic process|
|lymphocyte activation|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|hemopoiesis|
|proteolysis involved in cellular protein catabolic process|
|hematopoietic or lymphoid organ development|
|cellular protein catabolic process|
|immune system development|
|protein catabolic process|
|regulation of cellular response to stress|
|nucleolus|
|cellular macromolecule catabolic process|
|leukocyte activation|
|endoplasmic reticulum membrane|
|response to organonitrogen compound|
|endoplasmic reticulum|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell activation|
|response to nitrogen compound|
|negative regulation of signal transduction|
|proteolysis|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|negative regulation of response to stimulus|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.03|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.99|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.81|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.73|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.74|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17235
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAJB9 Expression in NALM6 Cells: 3.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>