DNAJB9

Gene Information

Official Symbol: DNAJB9
Official Name: DnaJ heat shock protein family (Hsp40) member B9
Aliases and Previous Symbols: N/A
Entrez ID: 4189
UniProt: Q9UBS3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity). {ECO:0000250|UniProtKB:G3H0N9, ECO:0000250|UniProtKB:Q9QYI6, ECO:0000269|PubMed:18400946}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MK-1775 0.32μM R02 exp75	-2.03
Campthothecin 0.001μM R06 exp270	-1.99
Amiloride 100μM R08 exp447	-1.81
TRAIL 5ng/ml R00 exp35	1.73
proTAME 5μM R04 exp187	1.74
GSK461364A 0.005μM R03 exp125	2.06

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17235
Expression level (log2 read counts): 3.55

Expression Distribution

negative regulation of IRE1-mediated unfolded protein response
negative regulation of endoplasmic reticulum unfolded protein response
regulation of IRE1-mediated unfolded protein response
regulation of endoplasmic reticulum unfolded protein response
misfolded protein binding
Hsp70 protein binding
negative regulation of response to endoplasmic reticulum stress
IRE1-mediated unfolded protein response
ubiquitin-dependent ERAD pathway
regulation of response to endoplasmic reticulum stress
ERAD pathway
chaperone binding
endoplasmic reticulum unfolded protein response
B cell differentiation
cellular response to unfolded protein
cellular response to topologically incorrect protein
B cell activation
immunoglobulin production
response to unfolded protein
production of molecular mediator of immune response
response to topologically incorrect protein
lymphocyte differentiation
response to endoplasmic reticulum stress
endoplasmic reticulum lumen
proteasome-mediated ubiquitin-dependent protein catabolic process
leukocyte differentiation
proteasomal protein catabolic process
lymphocyte activation
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
hemopoiesis
proteolysis involved in cellular protein catabolic process
hematopoietic or lymphoid organ development
cellular protein catabolic process
immune system development
protein catabolic process
regulation of cellular response to stress
nucleolus
cellular macromolecule catabolic process