DNAJC15 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= DNAJC15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAJC15
  * **<color #00a2e8>Official Name</color>**: DnaJ heat shock protein family (Hsp40) member C15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29103|29103]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5T4|Q9Y5T4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAJC15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAJC15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615339|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9. {ECO:0000250, ECO:0000269|PubMed:23263864}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DnaJ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of mitochondrial electron transport, NADH to ubiquinone|
|negative regulation of mitochondrial ATP synthesis coupled electron transport|
|negative regulation of cellular respiration|
|PAM complex, Tim23 associated import motor|
|regulation of mitochondrial electron transport, NADH to ubiquinone|
|negative regulation of oxidative phosphorylation|
|regulation of mitochondrial ATP synthesis coupled electron transport|
|protein import into mitochondrial matrix|
|ATPase activator activity|
|negative regulation of ATP metabolic process|
|regulation of oxidative phosphorylation|
|regulation of cellular respiration|
|protein transmembrane import into intracellular organelle|
|intracellular protein transmembrane transport|
|positive regulation of ATPase activity|
|protein targeting to mitochondrion|
|protein transmembrane transport|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|regulation of ATPase activity|
|mitochondrial transmembrane transport|
|regulation of ATP metabolic process|
|negative regulation of protein complex assembly|
|protein import|
|cellular response to starvation|
|regulation of generation of precursor metabolites and energy|
|response to starvation|
|mitochondrial transport|
|cellular response to nutrient levels|
|cellular response to extracellular stimulus|
|cellular response to external stimulus|
|protein targeting|
|regulation of lipid metabolic process|
|establishment of protein localization to organelle|
|mitochondrion organization|
|negative regulation of phosphorylation|
|regulation of protein complex assembly|
|response to nutrient levels|
|response to extracellular stimulus|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cellular component organization|
|protein localization to organelle|
|positive regulation of hydrolase activity|
|regulation of cellular component biogenesis|
|intracellular protein transport|
|regulation of hydrolase activity|
|transmembrane transport|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular response to stress|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.72|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.7|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.7|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.8|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18167
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAJC15 Expression in NALM6 Cells: -0.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>