DNAJC15

Gene Information

Official Symbol: DNAJC15
Official Name: DnaJ heat shock protein family (Hsp40) member C15
Aliases and Previous Symbols: N/A
Entrez ID: 29103
UniProt: Q9Y5T4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9. {ECO:0000250, ECO:0000269|PubMed:23263864}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
JQ1 0.01μM R03 exp130	-1.72
CVT-10216 0.1μM R06 exp278	-1.7
Alpha-Amanitin 0.5μM R00 exp5	1.7
RO-3306 3 to 4μM on day4 R04 exp165	1.8
Ribavirin 10 to 15μM on day4 R04 exp160	2

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18167
Expression level (log2 read counts): -0.77

Expression Distribution

negative regulation of mitochondrial electron transport, NADH to ubiquinone
negative regulation of mitochondrial ATP synthesis coupled electron transport
negative regulation of cellular respiration
PAM complex, Tim23 associated import motor
regulation of mitochondrial electron transport, NADH to ubiquinone
negative regulation of oxidative phosphorylation
regulation of mitochondrial ATP synthesis coupled electron transport
protein import into mitochondrial matrix
ATPase activator activity
negative regulation of ATP metabolic process
regulation of oxidative phosphorylation
regulation of cellular respiration
protein transmembrane import into intracellular organelle
intracellular protein transmembrane transport
positive regulation of ATPase activity
protein targeting to mitochondrion
protein transmembrane transport
establishment of protein localization to mitochondrion
protein localization to mitochondrion
regulation of ATPase activity
mitochondrial transmembrane transport
regulation of ATP metabolic process
negative regulation of protein complex assembly
protein import
cellular response to starvation
regulation of generation of precursor metabolites and energy
response to starvation
mitochondrial transport
cellular response to nutrient levels
cellular response to extracellular stimulus
cellular response to external stimulus
protein targeting
regulation of lipid metabolic process
establishment of protein localization to organelle
mitochondrion organization
negative regulation of phosphorylation
regulation of protein complex assembly
response to nutrient levels
response to extracellular stimulus
negative regulation of phosphate metabolic process