DOCK2

Entrez Summary: The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016].
UniProt Summary: Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
CI-1040 9.5μM R08 exp472	1.73
Docetaxel 0.002μM R01 exp45	1.92

membrane raft polarization
myeloid dendritic cell activation involved in immune response
alpha-beta T cell proliferation
membrane raft distribution
membrane raft localization
establishment of T cell polarity
establishment of lymphocyte polarity
T cell receptor binding
macropinocytosis
positive thymic T cell selection
negative thymic T cell selection
negative T cell selection
pinocytosis
immunological synapse formation
Rac guanyl-nucleotide exchange factor activity
thymic T cell selection
membrane raft organization
myeloid dendritic cell activation
positive T cell selection
regulation of defense response to virus by virus
T cell proliferation
T cell selection
T cell differentiation in thymus
alpha-beta T cell activation
specific granule lumen
positive regulation of phagocytosis
cell-cell recognition
lymphocyte proliferation
localization within membrane
mononuclear cell proliferation
regulation of phagocytosis
leukocyte proliferation
establishment of cell polarity
T cell differentiation
establishment or maintenance of cell polarity
T cell activation
lymphocyte differentiation
cell recognition
GTPase activator activity
small GTPase mediated signal transduction