DOCK7 [The Human Chemical-Genetic Interaction Map Project]

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======= DOCK7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DOCK7
  * **<color #00a2e8>Official Name</color>**: dedicator of cytokinesis 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=85440|85440]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96N67|Q96N67]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DOCK7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DOCK7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615730|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3398|
|Ded cyto|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment or maintenance of neuroblast polarity|
|establishment of neuroblast polarity|
|interkinetic nuclear migration|
|asymmetric neuroblast division|
|asymmetric stem cell division|
|basal part of cell|
|neuronal stem cell division|
|neuroblast division|
|positive regulation of vascular associated smooth muscle cell migration|
|asymmetric cell division|
|regulation of vascular associated smooth muscle cell migration|
|nuclear migration|
|somatic stem cell division|
|nucleus localization|
|cell proliferation in forebrain|
|neuroblast proliferation|
|stem cell division|
|COP9 signalosome|
|positive regulation of smooth muscle cell migration|
|negative regulation of cold-induced thermogenesis|
|stem cell proliferation|
|Rac GTPase binding|
|regulation of smooth muscle cell migration|
|neural precursor cell proliferation|
|activation of GTPase activity|
|guanyl-nucleotide exchange factor activity|
|positive regulation of peptidyl-serine phosphorylation|
|establishment of cell polarity|
|growth cone|
|regulation of peptidyl-serine phosphorylation|
|regulation of cold-induced thermogenesis|
|establishment or maintenance of cell polarity|
|cell fate commitment|
|axon|
|small GTPase mediated signal transduction|
|neuron projection|
|establishment of organelle localization|
|axonogenesis|
|forebrain development|
|axon development|
|positive regulation of GTPase activity|
|focal adhesion|
|cell morphogenesis involved in neuron differentiation|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell division|
|positive regulation of cell migration|
|cell part morphogenesis|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|organelle localization|
|neuron projection development|
|microtubule-based process|
|cell morphogenesis|
|brain development|
|positive regulation of hydrolase activity|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|intracellular transport|
|generation of neurons|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|establishment of localization in cell|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.92|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.79|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5969
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DOCK7 Expression in NALM6 Cells: 5.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>