DOCK8 [The Human Chemical-Genetic Interaction Map Project]

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======= DOCK8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DOCK8
  * **<color #00a2e8>Official Name</color>**: dedicator of cytokinesis 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81704|81704]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NF50|Q8NF50]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DOCK8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DOCK8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611432|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ded cyto|
|DUF3398|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|memory T cell proliferation|
|positive regulation of establishment of T cell polarity|
|regulation of establishment of T cell polarity|
|leading edge membrane|
|immunological synapse formation|
|negative regulation of T cell apoptotic process|
|regulation of establishment of cell polarity|
|dendritic cell migration|
|lamellipodium membrane|
|regulation of establishment or maintenance of cell polarity|
|negative regulation of lymphocyte apoptotic process|
|positive regulation of T cell migration|
|regulation of T cell apoptotic process|
|positive regulation of lymphocyte migration|
|T cell proliferation|
|regulation of T cell migration|
|negative regulation of leukocyte apoptotic process|
|regulation of lymphocyte apoptotic process|
|regulation of lymphocyte migration|
|cell-cell recognition|
|regulation of leukocyte apoptotic process|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|cellular response to chemokine|
|response to chemokine|
|leukocyte proliferation|
|guanyl-nucleotide exchange factor activity|
|positive regulation of leukocyte migration|
|regulation of leukocyte migration|
|positive regulation of T cell activation|
|positive regulation of leukocyte cell-cell adhesion|
|T cell activation|
|cell recognition|
|positive regulation of cell-cell adhesion|
|blood coagulation|
|coagulation|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|regulation of T cell activation|
|small GTPase mediated signal transduction|
|positive regulation of lymphocyte activation|
|leukocyte migration|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of GTPase activity|
|positive regulation of cell activation|
|wound healing|
|regulation of GTPase activity|
|regulation of body fluid levels|
|positive regulation of cell migration|
|regulation of lymphocyte activation|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|cell population proliferation|
|response to wounding|
|regulation of leukocyte activation|
|regulation of cell activation|
|regulation of cell adhesion|
|positive regulation of hydrolase activity|
|regulation of cell migration|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|leukocyte activation|
|cell migration|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|cell activation|
|localization of cell|
|cell motility|
|response to cytokine|
|positive regulation of immune system process|
|regulation of hydrolase activity|
|locomotion|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of molecular function|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11665
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DOCK8 Expression in NALM6 Cells: 3.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>