DOCK8

• Official Symbol: DOCK8
• Official Name: dedicator of cytokinesis 8
• Aliases and Previous Symbols: N/A
• Entrez ID: 81704
• UniProt: Q8NF50
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010].
• UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 11665
• Expression level (log2 read counts): 3.4

Expression Distribution

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DOCK8 Expression in NALM6 Cells: 3.4