DPEP1
Gene Information
- Official Symbol: DPEP1
- Official Name: dipeptidase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1800
- UniProt: P16444
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity.
Pfam Domains GO Terms
Pfam Domains
| Peptidase M19 |
GO Terms
| cellular lactam catabolic process |
| cellular lactam metabolic process |
| cellular amide catabolic process |
| metallodipeptidase activity |
| modified amino acid binding |
| GPI anchor binding |
| homocysteine metabolic process |
| metalloexopeptidase activity |
| dipeptidyl-peptidase activity |
| cellular response to nitric oxide |
| cellular response to reactive nitrogen species |
| response to nitric oxide |
| microvillus membrane |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| leukotriene metabolic process |
| sulfur amino acid metabolic process |
| response to bronchodilator |
| glutathione metabolic process |
| apical part of cell |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| cellular response to calcium ion |
| negative regulation of cysteine-type endopeptidase activity |
| anchored component of membrane |
| antibiotic metabolic process |
| icosanoid metabolic process |
| cellular response to reactive oxygen species |
| xenobiotic metabolic process |
| response to calcium ion |
| fatty acid derivative metabolic process |
| cellular response to xenobiotic stimulus |
| cellular response to metal ion |
| response to reactive oxygen species |
| cellular modified amino acid metabolic process |
| alpha-amino acid metabolic process |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| cellular response to inorganic substance |
| cellular response to oxidative stress |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| negative regulation of peptidase activity |
| negative regulation of cell migration |
| negative regulation of cell motility |
| response to xenobiotic stimulus |
| negative regulation of cellular component movement |
| cellular amino acid metabolic process |
| apical plasma membrane |
| negative regulation of locomotion |
| negative regulation of proteolysis |
| sulfur compound metabolic process |
| response to metal ion |
| response to oxidative stress |
| cellular response to drug |
| regulation of endopeptidase activity |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| cofactor metabolic process |
| regulation of peptidase activity |
| negative regulation of hydrolase activity |
| drug metabolic process |
| peptide metabolic process |
| response to inorganic substance |
| cell junction |
| cellular response to nitrogen compound |
| regulation of proteolysis |
| cellular amide metabolic process |
| negative regulation of catalytic activity |
| zinc ion binding |
| regulation of cell migration |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| carboxylic acid metabolic process |
| regulation of cell motility |
| apoptotic process |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of cell death |
| oxoacid metabolic process |
| response to drug |
| organic acid metabolic process |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| cell death |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| proteolysis |
| regulation of hydrolase activity |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| extracellular space |
| regulation of cell death |
| cellular response to stress |
| small molecule metabolic process |
| cellular catabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Dexamethasone 0.006μM R07 exp351 | 2.4 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6323
- Expression level (log2 read counts): -0.25
Expression Distribution
DPEP1 Expression in NALM6 Cells: -0.25
