DPM3 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= DPM3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DPM3
  * **<color #00a2e8>Official Name</color>**: dolichyl-phosphate mannosyltransferase subunit 3, regulatory
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54344|54344]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P2X0|Q9P2X0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DPM3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DPM3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605951|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER. {ECO:0000269|PubMed:10835346}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DPM3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mannosyltransferase complex|
|dolichol-phosphate-mannose synthase complex|
|dolichyl-phosphate beta-D-mannosyltransferase activity|
|peptidyl-tryptophan modification|
|protein C-linked glycosylation via 2-alpha-mannosyl-L-tryptophan|
|protein C-linked glycosylation via tryptophan|
|protein C-linked glycosylation|
|protein O-linked mannosylation|
|protein mannosylation|
|GPI anchor biosynthetic process|
|GPI anchor metabolic process|
|protein N-linked glycosylation via asparagine|
|peptidyl-asparagine modification|
|mannosylation|
|glycolipid biosynthetic process|
|protein N-linked glycosylation|
|protein lipidation|
|lipoprotein biosynthetic process|
|integral component of endoplasmic reticulum membrane|
|glycolipid metabolic process|
|phosphatidylinositol biosynthetic process|
|liposaccharide metabolic process|
|protein O-linked glycosylation|
|lipoprotein metabolic process|
|membrane lipid biosynthetic process|
|phosphatidylinositol metabolic process|
|membrane lipid metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|regulation of protein stability|
|glycerophospholipid metabolic process|
|glycoprotein biosynthetic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|glycoprotein metabolic process|
|carbohydrate metabolic process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|carbohydrate derivative biosynthetic process|
|peptidyl-amino acid modification|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-2.36|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:alg9|ALG9]]|0.633|
|[[:human genes:a:alg6|ALG6]]|0.539|
|[[:human genes:m:mpdu1|MPDU1]]|0.531|
|[[:human genes:d:dpm1|DPM1]]|0.53|
|[[:human genes:a:alg3|ALG3]]|0.53|
|[[:human genes:s:sec62|SEC62]]|0.493|
|[[:human genes:s:sec63|SEC63]]|0.492|
|[[:human genes:d:dhrsx|DHRSX]]|0.48|
|[[:human genes:a:alg5|ALG5]]|0.463|
|[[:human genes:m:mbtps2|MBTPS2]]|0.451|
|[[:human genes:d:dnajc3|DNAJC3]]|0.448|
|[[:human genes:s:srd5a3|SRD5A3]]|0.438|
|[[:human genes:c:cbfb|CBFB]]|0.435|
|[[:human genes:a:alg12|ALG12]]|0.433|
|[[:human genes:a:alg8|ALG8]]|0.427|
|[[:human genes:m:manf|MANF]]|0.421|
|[[:human genes:d:dpagt1|DPAGT1]]|0.417|
|[[:human genes:a:alg1|ALG1]]|0.417|
|[[:human genes:c:chka|CHKA]]|0.409|
|[[:human genes:d:dolk|DOLK]]|0.408|
|[[:human genes:u:ugp2|UGP2]]|0.407|
|[[:human genes:a:atp2a2|ATP2A2]]|0.406|
|[[:human genes:d:dnajb11|DNAJB11]]|0.403|
|[[:human genes:p:pmm2|PMM2]]|0.4|
|[[:human genes:t:trmt61a|TRMT61A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5159
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DPM3 Expression in NALM6 Cells: 2.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>