DPM3

Entrez Summary: Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. [provided by RefSeq, Jul 2008].
UniProt Summary: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER. {ECO:0000269|PubMed:10835346}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 6/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	3/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Bisphenol S 100μM R08 exp458	-2.36
LY2090314 0.003μM R08 exp499	1.77

mannosyltransferase complex
dolichol-phosphate-mannose synthase complex
dolichyl-phosphate beta-D-mannosyltransferase activity
peptidyl-tryptophan modification
protein C-linked glycosylation via 2-alpha-mannosyl-L-tryptophan
protein C-linked glycosylation via tryptophan
protein C-linked glycosylation
protein O-linked mannosylation
protein mannosylation
GPI anchor biosynthetic process
GPI anchor metabolic process
protein N-linked glycosylation via asparagine
peptidyl-asparagine modification
mannosylation
glycolipid biosynthetic process
protein N-linked glycosylation
protein lipidation
lipoprotein biosynthetic process
integral component of endoplasmic reticulum membrane
glycolipid metabolic process
phosphatidylinositol biosynthetic process
liposaccharide metabolic process
protein O-linked glycosylation
lipoprotein metabolic process
membrane lipid biosynthetic process
phosphatidylinositol metabolic process
membrane lipid metabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
macromolecule glycosylation
protein glycosylation
glycosylation
regulation of protein stability
glycerophospholipid metabolic process
glycoprotein biosynthetic process
phospholipid metabolic process
glycerolipid metabolic process
glycoprotein metabolic process
carbohydrate metabolic process