DSG3

Entrez Summary: N/A
UniProt Summary: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Cadherin C
Cadherin

desmosome
cornified envelope
cornification
homophilic cell adhesion via plasma membrane adhesion molecules
cell-cell junction
keratinization
cell-cell adhesion via plasma-membrane adhesion molecules
keratinocyte differentiation
epidermal cell differentiation
skin development
epidermis development
cell-cell adhesion
epithelial cell differentiation
calcium ion binding
cell adhesion
biological adhesion
programmed cell death
cell death
epithelium development
tissue development