DYNAP

Entrez Summary: N/A
UniProt Summary: Plays a role in the regulation of cell proliferation. Promotes activation of the AKT1 signaling pathway. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:20978158}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cellular response to ergosterol
cellular response to sterol
response to sterol
activation of protein kinase B activity
cellular response to alcohol
response to alcohol
activation of protein kinase activity
cellular response to lipid
positive regulation of protein kinase activity
cellular response to organic cyclic compound
positive regulation of kinase activity
Golgi membrane
positive regulation of transferase activity
regulation of protein kinase activity
response to lipid
regulation of kinase activity
positive regulation of cell population proliferation
response to organic cyclic compound
regulation of transferase activity
Golgi apparatus
positive regulation of protein phosphorylation
cellular response to oxygen-containing compound
positive regulation of phosphorylation
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
positive regulation of protein modification process
positive regulation of catalytic activity
regulation of protein phosphorylation
regulation of apoptotic process
response to oxygen-containing compound
regulation of programmed cell death
regulation of phosphorylation
positive regulation of cellular protein metabolic process
regulation of cell population proliferation
regulation of cell death
positive regulation of protein metabolic process
positive regulation of molecular function
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process