DYNLL2

Entrez Summary: N/A
UniProt Summary: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

myosin V complex
positive regulation of ATP-dependent microtubule motor activity, plus-end-directed
regulation of ATP-dependent microtubule motor activity, plus-end-directed
positive regulation of microtubule motor activity
regulation of microtubule motor activity
cytoplasmic dynein complex
dynein complex
ATP-dependent microtubule motor activity, plus-end-directed
dynein light intermediate chain binding
dynein intermediate chain binding
intraciliary transport involved in cilium assembly
ciliary tip
intraciliary transport
positive regulation of ATPase activity
scaffold protein binding
protein transport along microtubule
microtubule-based protein transport
regulation of ATPase activity
postsynapse
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
transport along microtubule
macroautophagy
cytoskeleton-dependent intracellular transport
antigen processing and presentation of exogenous peptide antigen
microtubule-based transport
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
cilium
endoplasmic reticulum to Golgi vesicle-mediated transport
antigen processing and presentation
postsynaptic density
protein-containing complex localization
autophagy
process utilizing autophagic mechanism
microtubule-based movement
microtubule
cilium assembly
glutamatergic synapse