EDAR

Entrez Summary: This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Lapatinib 5μM R01 exp47	-2.52
Mubritinib 0.2μM R01 exp48	-1.78

tube lumen cavitation
salivary gland cavitation
salivary gland morphogenesis
salivary gland development
exocrine system development
hair follicle development
apical part of cell
skin epidermis development
molting cycle process
hair cycle process
positive regulation of NIK/NF-kappaB signaling
odontogenesis of dentin-containing tooth
pigmentation
hair cycle
molting cycle
gland morphogenesis
regulation of NIK/NF-kappaB signaling
tumor necrosis factor-mediated signaling pathway
odontogenesis
transmembrane signaling receptor activity
positive regulation of JNK cascade
tube formation
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of JNK cascade
signaling receptor activity
regulation of stress-activated MAPK cascade
regulation of I-kappaB kinase/NF-kappaB signaling
regulation of stress-activated protein kinase signaling cascade
cellular response to tumor necrosis factor
response to tumor necrosis factor
skin development
gland development
epidermis development
positive regulation of MAPK cascade
tube morphogenesis
cytokine-mediated signaling pathway
regulation of cellular response to stress
regulation of MAPK cascade