EEF1A2

Entrez Summary: This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. [provided by RefSeq, Mar 2014].
UniProt Summary: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

eukaryotic translation elongation factor 1 complex
cytoplasmic side of lysosomal membrane
regulation of chaperone-mediated autophagy
translation elongation factor activity
translation factor activity, RNA binding
positive regulation of lipid kinase activity
response to electrical stimulus
regulation of lipid kinase activity
translational elongation
positive regulation of lipid metabolic process
synapse
GTPase activity
regulation of autophagy
neuronal cell body
translation
regulation of protein catabolic process
GTP binding
regulation of lipid metabolic process
peptide biosynthetic process
protein kinase binding
amide biosynthetic process
peptide metabolic process
response to inorganic substance
positive regulation of kinase activity
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of transferase activity
positive regulation of cell death
cellular amide metabolic process
regulation of cellular catabolic process
regulation of kinase activity
regulation of transferase activity
regulation of catabolic process
positive regulation of phosphorylation
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
response to abiotic stimulus
organonitrogen compound biosynthetic process
positive regulation of catalytic activity
regulation of apoptotic process