EFCAB7

Gene Information

Official Symbol: EFCAB7
Official Name: EF-hand calcium binding domain 7
Aliases and Previous Symbols: N/A
Entrez ID: 84455
UniProt: A8K855
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia. {ECO:0000250|UniProtKB:Q8VDY4}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11055
Expression level (log2 read counts): 3.06

Expression Distribution

positive regulation of protein localization to ciliary membrane
regulation of protein localization to ciliary membrane
positive regulation of protein localization to cilium
plasma membrane protein complex
regulation of protein localization to cilium
positive regulation of protein import into nucleus
positive regulation of protein import
ciliary membrane
regulation of protein import into nucleus
regulation of protein import
positive regulation of protein localization to cell periphery
positive regulation of nucleocytoplasmic transport
extrinsic component of membrane
positive regulation of protein localization to nucleus
regulation of nucleocytoplasmic transport
regulation of protein localization to cell periphery
regulation of protein localization to nucleus
positive regulation of protein localization to membrane
positive regulation of intracellular protein transport
regulation of protein localization to membrane
cilium
positive regulation of intracellular transport
regulation of intracellular protein transport
positive regulation of cellular protein localization
regulation of intracellular transport
positive regulation of protein transport
positive regulation of establishment of protein localization
regulation of cellular protein localization
regulation of protein transport
calcium ion binding
regulation of peptide transport
regulation of establishment of protein localization
regulation of cellular localization
positive regulation of transport
regulation of protein localization
positive regulation of transcription by RNA polymerase II
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process