EFNA3 [The Human Chemical-Genetic Interaction Map Project]

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======= EFNA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EFNA3
  * **<color #00a2e8>Official Name</color>**: ephrin A3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1944|1944]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52797|P52797]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EFNA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EFNA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601381|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ephrin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|
|positive regulation of aspartic-type peptidase activity|
|regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|
|regulation of aspartic-type peptidase activity|
|transmembrane-ephrin receptor activity|
|positive regulation of amyloid precursor protein catabolic process|
|ephrin receptor binding|
|regulation of amyloid precursor protein catabolic process|
|intrinsic component of plasma membrane|
|ephrin receptor signaling pathway|
|anchored component of membrane|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|negative regulation of vasculature development|
|positive regulation of endopeptidase activity|
|positive regulation of peptidase activity|
|axon guidance|
|neuron projection guidance|
|regulation of angiogenesis|
|regulation of vasculature development|
|positive regulation of proteolysis|
|axonogenesis|
|axon development|
|regulation of endopeptidase activity|
|cell morphogenesis involved in neuron differentiation|
|regulation of peptidase activity|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|neuron projection development|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|neuron development|
|cellular component morphogenesis|
|negative regulation of developmental process|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|regulation of hydrolase activity|
|locomotion|
|positive regulation of catalytic activity|
|generation of neurons|
|movement of cell or subcellular component|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.454|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9121
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EFNA3 Expression in NALM6 Cells: 0.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>