EFNA3

Gene Information

Official Symbol: EFNA3
Official Name: ephrin A3
Aliases and Previous Symbols: N/A
Entrez ID: 1944
UniProt: P52797
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9121
Expression level (log2 read counts): 0.96

Expression Distribution

positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
positive regulation of aspartic-type peptidase activity
regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
regulation of aspartic-type peptidase activity
transmembrane-ephrin receptor activity
positive regulation of amyloid precursor protein catabolic process
ephrin receptor binding
regulation of amyloid precursor protein catabolic process
intrinsic component of plasma membrane
ephrin receptor signaling pathway
anchored component of membrane
negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
negative regulation of vasculature development
positive regulation of endopeptidase activity
positive regulation of peptidase activity
axon guidance
neuron projection guidance
regulation of angiogenesis
regulation of vasculature development
positive regulation of proteolysis
axonogenesis
axon development
regulation of endopeptidase activity
cell morphogenesis involved in neuron differentiation
regulation of peptidase activity
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
transmembrane receptor protein tyrosine kinase signaling pathway
cell part morphogenesis
chemotaxis
taxis
cell morphogenesis involved in differentiation
neuron projection development
enzyme linked receptor protein signaling pathway
cell morphogenesis
regulation of proteolysis
positive regulation of hydrolase activity
neuron development