EGR1
Gene Information
- Official Symbol: EGR1
- Official Name: early growth response 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1958
- UniProt: P18146
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014].
- UniProt Summary: Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double- stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). {ECO:0000250|UniProtKB:P08046, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311}.
Pfam Domains GO Terms
Pfam Domains
| DUF3446 |
| DUF3432 |
GO Terms
| positive regulation of glomerular metanephric mesangial cell proliferation |
| regulation of metanephric glomerular mesangial cell proliferation |
| response to mycophenolic acid |
| glomerular mesangial cell proliferation |
| cellular response to mycophenolic acid |
| circadian temperature homeostasis |
| cellular response to interleukin-8 |
| hemi-methylated DNA-binding |
| response to interleukin-8 |
| regulation of progesterone biosynthetic process |
| cellular response to mycotoxin |
| double-stranded methylated DNA binding |
| cellular response to heparin |
| positive regulation of metanephric glomerulus development |
| regulation of metanephric glomerulus development |
| response to heparin |
| positive regulation of glomerular mesangial cell proliferation |
| positive regulation of tau-protein kinase activity |
| regulation of interleukin-1 biosynthetic process |
| positive regulation of interleukin-1 biosynthetic process |
| regulation of interleukin-1 beta biosynthetic process |
| positive regulation of interleukin-1 beta biosynthetic process |
| response to mycotoxin |
| response to anticoagulant |
| glomerular mesangium development |
| positive regulation of cell proliferation involved in kidney development |
| regulation of glomerular mesangial cell proliferation |
| cell proliferation involved in kidney development |
| regulation of tau-protein kinase activity |
| positive regulation of hormone biosynthetic process |
| positive regulation of glomerulus development |
| locomotor rhythm |
| positive regulation of chemokine biosynthetic process |
| regulation of cell proliferation involved in kidney development |
| positive regulation of metanephros development |
| regulation of chemokine biosynthetic process |
| positive regulation of hormone metabolic process |
| regulation of glomerulus development |
| regulation of ketone biosynthetic process |
| estrous cycle |
| glomerulus vasculature development |
| renal system vasculature development |
| kidney vasculature development |
| regulation of protein sumoylation |
| regulation of metanephros development |
| circadian behavior |
| rhythmic behavior |
| regulation of hormone biosynthetic process |
| histone acetyltransferase binding |
| temperature homeostasis |
| cellular response to gamma radiation |
| regulation of hormone metabolic process |
| positive regulation of kidney development |
| response to ischemia |
| promoter-specific chromatin binding |
| skeletal muscle cell differentiation |
| positive regulation of interleukin-1 beta production |
| glomerulus development |
| regulation of kidney development |
| response to gamma radiation |
| positive regulation of chemokine production |
| positive regulation of interleukin-1 production |
| circadian regulation of gene expression |
| cellular response to type I interferon |
| type I interferon signaling pathway |
| ovulation cycle |
| positive regulation of cytokine biosynthetic process |
| cellular response to ionizing radiation |
| response to type I interferon |
| transcription regulatory region sequence-specific DNA binding |
| regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| regulation of chemokine production |
| regulation of interleukin-1 beta production |
| metanephros development |
| regulation of steroid biosynthetic process |
| BMP signaling pathway |
| positive regulation of neuron death |
| regulation of interleukin-1 production |
| response to antineoplastic agent |
| interleukin-1-mediated signaling pathway |
| regulation of cytokine biosynthetic process |
| cellular response to BMP stimulus |
| response to BMP |
| regulation of steroid metabolic process |
| cellular response to antibiotic |
| regulation of transcription from RNA polymerase II promoter in response to stress |
| skeletal muscle tissue development |
| nephron development |
| regulation of DNA-templated transcription in response to stress |
| skeletal muscle organ development |
| T cell differentiation |
| response to glucose |
| circadian rhythm |
| response to hexose |
| response to ionizing radiation |
| response to monosaccharide |
| response to carbohydrate |
| regulation of cellular ketone metabolic process |
| cellular response to radiation |
| negative regulation of canonical Wnt signaling pathway |
| cellular response to interleukin-1 |
| positive regulation of vasculature development |
| cellular response to xenobiotic stimulus |
| regulation of lipid biosynthetic process |
| cellular response to hypoxia |
| locomotory behavior |
| cellular response to decreased oxygen levels |
| response to interleukin-1 |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| cellular response to acid chemical |
| negative regulation of Wnt signaling pathway |
| cellular response to toxic substance |
| cellular response to oxygen levels |
| connective tissue development |
| response to insulin |
| regulation of protein modification by small protein conjugation or removal |
| T cell activation |
| lymphocyte differentiation |
| kidney development |
| rhythmic process |
| regulation of canonical Wnt signaling pathway |
| striated muscle tissue development |
| renal system development |
| muscle organ development |
| muscle tissue development |
| response to xenobiotic stimulus |
| response to antibiotic |
| regulation of neuron death |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| urogenital system development |
| regulation of vasculature development |
| multicellular organismal homeostasis |
| leukocyte differentiation |
| response to hypoxia |
| response to acid chemical |
| response to decreased oxygen levels |
| regulation of Wnt signaling pathway |
| response to oxygen levels |
| lymphocyte activation |
| response to peptide hormone |
| regulation of lipid metabolic process |
| cellular response to drug |
| sequence-specific DNA binding |
| regulation of small molecule metabolic process |
| response to radiation |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| positive regulation of cytokine production |
| response to peptide |
| muscle structure development |
| transcription by RNA polymerase II |
| blood vessel development |
| cellular response to growth factor stimulus |
| response to toxic substance |
| vasculature development |
| cardiovascular system development |
| response to growth factor |
| positive regulation of protein kinase activity |
| regulation of hormone levels |
| cellular response to organic cyclic compound |
| cell population proliferation |
| hemopoiesis |
| behavior |
| positive regulation of kinase activity |
| cellular response to organonitrogen compound |
| hematopoietic or lymphoid organ development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| immune system development |
| RNA biosynthetic process |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| cytokine-mediated signaling pathway |
| DNA-binding transcription factor activity |
| regulation of cytokine production |
| positive regulation of cell death |
| enzyme linked receptor protein signaling pathway |
| innate immune response |
| regulation of protein kinase activity |
| multicellular organismal reproductive process |
| zinc ion binding |
| multicellular organism reproduction |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| regulation of kinase activity |
| response to hormone |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| leukocyte activation |
| defense response to other organism |
| regulation of transferase activity |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| response to drug |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| cell activation |
| response to nitrogen compound |
| nucleobase-containing compound biosynthetic process |
| response to cytokine |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| response to abiotic stimulus |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| response to other organism |
| organic cyclic compound biosynthetic process |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| RNA metabolic process |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| GSK626616 14μM R08 exp485 | 1.71 |
| SB743921 0.001μM R05 exp244 | 1.73 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14735
- Expression level (log2 read counts): 1.97
Expression Distribution
EGR1 Expression in NALM6 Cells: 1.97
