EHD4

Entrez Summary: N/A
UniProt Summary: ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport. {ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:18331452}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Dynamin N
efhand 3

pinocytosis
endocytic recycling
recycling endosome membrane
early endosome membrane
positive regulation of peptidyl-tyrosine phosphorylation
nucleic acid binding
regulation of endocytosis
endosomal transport
regulation of peptidyl-tyrosine phosphorylation
cadherin binding
protein homooligomerization
GTP binding
cellular response to growth factor stimulus
protein complex oligomerization
response to growth factor
regulation of vesicle-mediated transport
endocytosis
import into cell
perinuclear region of cytoplasm
calcium ion binding
endoplasmic reticulum
positive regulation of protein phosphorylation
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of protein modification process
regulation of protein phosphorylation
ATP binding
intracellular transport
protein-containing complex assembly
regulation of phosphorylation
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
establishment of localization in cell
regulation of protein modification process
protein-containing complex subunit organization
regulation of transport
vesicle-mediated transport