EIF2B2

Entrez Summary: This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011].
UniProt Summary: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 641/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	21/28
blood	26/28
bone	21/26
breast	32/33
central nervous system	52/56
cervix	4/4
colorectal	16/17
esophagus	11/13
fibroblast	1/1
gastric	11/16
kidney	19/21
liver	20/20
lung	62/75
lymphocyte	13/16
ovary	22/26
pancreas	16/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	1/1
skin	21/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	17/22
urinary tract	23/29
uterus	3/5

Expression Distribution

Screen	Score
UM0011500 10μM R05 exp246	1.77
2-Methoxyestradiol 0.55μM R07 exp310	1.79

eukaryotic translation initiation factor 2B complex
oligodendrocyte development
ovarian follicle development
translation initiation factor activity
oligodendrocyte differentiation
regulation of translational initiation
female gonad development
development of primary female sexual characteristics
guanyl-nucleotide exchange factor activity
myelination
glial cell development
female sex differentiation
ensheathment of neurons
axon ensheathment
response to heat
response to glucose
translational initiation
response to hexose
response to monosaccharide
glial cell differentiation
response to carbohydrate
T cell receptor signaling pathway
response to temperature stimulus
gonad development
gliogenesis
development of primary sexual characteristics
sex differentiation
antigen receptor-mediated signaling pathway
regulation of translation
translation
GTP binding
response to peptide hormone
regulation of cellular amide metabolic process
peptide biosynthetic process
reproductive structure development
reproductive system development
immune response-activating cell surface receptor signaling pathway
response to peptide
immune response-regulating cell surface receptor signaling pathway
posttranscriptional regulation of gene expression