EIF2S2

Entrez Summary: N/A
UniProt Summary: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 48/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	2/28
blood	2/28
bone	2/26
breast	5/33
central nervous system	1/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	4/75
lymphocyte	2/16
ovary	2/26
pancreas	0/24
peripheral nervous system	2/16
plasma cell	2/15
prostate	0/1
skin	5/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

germ cell proliferation
male germ cell proliferation
eukaryotic translation initiation factor 2 complex
formation of translation preinitiation complex
formation of cytoplasmic translation initiation complex
translation initiation factor binding
translation factor activity, RNA binding
cytoplasmic translational initiation
translation initiation factor activity
cytoplasmic translation
male gonad development
development of primary male sexual characteristics
translational initiation
male sex differentiation
mRNA binding
gonad development
development of primary sexual characteristics
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
sex differentiation
in utero embryonic development
translation
peptide biosynthetic process
reproductive structure development
reproductive system development
ribonucleoprotein complex biogenesis
amide biosynthetic process
peptide metabolic process
cell population proliferation
chordate embryonic development
embryo development ending in birth or egg hatching
developmental process involved in reproduction
gamete generation
cellular amide metabolic process
multicellular organismal reproductive process
sexual reproduction
cellular protein-containing complex assembly
multicellular organism reproduction
embryo development
multi-organism reproductive process