EIF3K [The Human Chemical-Genetic Interaction Map Project]

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======= EIF3K =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF3K
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 3 subunit K
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27335|27335]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBQ5|Q9UBQ5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF3K&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF3K|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609596|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF- 3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03010, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAC3 GANP|
|PCI Csn8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eukaryotic 48S preinitiation complex|
|formation of cytoplasmic translation initiation complex|
|eukaryotic translation initiation factor 3 complex|
|eukaryotic 43S preinitiation complex|
|cytoplasmic translational initiation|
|translation initiation factor activity|
|ribosome binding|
|cytoplasmic translation|
|regulation of translational initiation|
|translational initiation|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|regulation of translation|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.62|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.12|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.97|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.96|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.8|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.75|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.78|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.79|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.83|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.84|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.84|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.85|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|2.09|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.42|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.88|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|3.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:eif3l|EIF3L]]|0.657|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.461|
|[[:human genes:a:atp13a1|ATP13A1]]|0.458|
|[[:human genes:s:smg7|SMG7]]|0.43|
|[[:human genes:m:mtf1|MTF1]]|0.409|
|[[:human genes:r:rpl30|RPL30]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1641
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF3K Expression in NALM6 Cells: 6.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>